Gosnell B A, Patel C K
Department of Psychiatry, University of Wisconsin-Madison, Parkway Hospital 53719.
Pharmacol Biochem Behav. 1993 Aug;45(4):979-82. doi: 10.1016/0091-3057(93)90151-i.
In previous reports, ICV administration of selective mu- or delta-opioid receptor agonists was found to stimulate the intake of saccharin and salt solutions in nondeprived rats. In the present study, we measured the effects of selective mu-, delta-, and kappa-agonists on operant responding for saccharin. The selective mu-agonist [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) and the selective delta-agonist [D-Thr2]-leucine enkephalin-Thr (DTLET) increased responding, whereas the kappa-agonist dynorphin A analog kappa ligand (DAKLI) had no significant effect. These results agree with previous studies on saccharin and salt intake and are consistent with the possibility that the effects of opioids on the intake of these fluids are mediated via enhancement of activity in brain reward pathways.
在之前的报告中，发现在未被剥夺食物的大鼠中，向脑室内注射选择性μ-或δ-阿片受体激动剂会刺激其摄入糖精和盐溶液。在本研究中，我们测量了选择性μ-、δ-和κ-激动剂对糖精操作性反应的影响。选择性μ-激动剂[D-丙氨酸2，N-甲基苯丙氨酸4，甘氨酸5-醇]-脑啡肽（DAMGO）和选择性δ-激动剂[D-苏氨酸2]-亮氨酸脑啡肽-苏氨酸（DTLET）增加了反应，而κ-激动剂强啡肽A类似物κ配体（DAKLI）没有显著影响。这些结果与之前关于糖精和盐摄入的研究一致，并且与阿片类药物对这些液体摄入的影响可能是通过增强脑奖赏通路的活性介导的这一可能性相符。
