Martin R J
Department of Preclinical Veterinary Sciences, University of Edinburgh, U.K.
Pharmacol Ther. 1993;58(1):13-50. doi: 10.1016/0163-7258(93)90065-l.
Some anthelmintic drugs interfere selectively with nematode neuromuscular transmission. These drugs include: the nicotinic agonists, e.g. levamisole, the gamma-amino butyric acid agonist piperazine, and the avermectins which open Cl- channels. The physiology and pharmacology of neuromuscular transmission in nematodes is reviewed and the actions of antinematodal drugs which interfere with the transmission described. The results of experiments on the large porcine-intestinal nematode parasite, Ascaris suum, form the basis of the account presented but experiments on other nematodes suggest that these observations may be generalized. Results of some experiments on the small free living nematode Caenorhabditis elegans are also included.
一些驱虫药可选择性地干扰线虫的神经肌肉传递。这些药物包括：烟碱激动剂，如左旋咪唑；γ-氨基丁酸激动剂哌嗪；以及能打开氯离子通道的阿维菌素。本文综述了线虫神经肌肉传递的生理学和药理学，并描述了干扰该传递的抗线虫药物的作用。对大型猪肠道线虫寄生虫猪蛔虫所做实验的结果构成了本文叙述的基础，但对其他线虫所做的实验表明，这些观察结果可能具有普遍性。本文还纳入了一些对小型自由生活线虫秀丽隐杆线虫所做实验的结果。
