小鼠干扰素-β三维晶体结构的结构、功能及进化意义

Structural, functional and evolutionary implications of the three-dimensional crystal structure of murine interferon-beta.

作者信息

Mitsui Y, Senda T, Shimazu T, Matsuda S, Utsumi J

机构信息

Department of BioEngineering, Nagaoka University of Technology, Niigata, Japan.

出版信息

Pharmacol Ther. 1993;58(1):93-132. doi: 10.1016/0163-7258(93)90068-o.

DOI:10.1016/0163-7258(93)90068-o

PMID:8415875

Abstract

The crystal structure of recombinant murine interferon-beta as elucidated by Senda et al. (Proc. Jap. Acad. 66B: 77-80 (1990); EMBO J. 11: 3193-3201 (1992)) appears to represent the basic structural framework of all Type I interferons including interferons-beta and all subtypes of interferons-alpha of various mammalian origin. Now the huge accumulated data on the structure-activity relationship of Type I interferons using various chemical and genetic techniques can be systematically evaluated in terms of the three-dimensional structure. Structural comparison with other cytokines, for which three-dimensional structures have been established, including interferon-gamma and considerations on the evolution of cytokines and cytokine receptors are also given.

摘要

Senda等人阐明的重组鼠干扰素-β的晶体结构（《日本科学院院报》66B：77 - 80 (1990)；《欧洲分子生物学组织杂志》11：3193 - 3201 (1992)）似乎代表了所有I型干扰素的基本结构框架，包括β干扰素以及各种哺乳动物来源的α干扰素的所有亚型。现在，可以根据三维结构系统地评估利用各种化学和基因技术积累的关于I型干扰素结构 - 活性关系的大量数据。还给出了与已确定三维结构的其他细胞因子（包括γ干扰素）的结构比较，以及对细胞因子和细胞因子受体进化的考虑。