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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Shelton R C, Loosen P T

Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN.

Prog Neuropsychopharmacol Biol Psychiatry. 1993 Jan;17(1):113-23. doi: 10.1016/0278-5846(93)90036-r.

The authors examined the effect of total sleep deprivation (SD) in combination with nortriptyline in 20 patients with major depressive disorder (MDD). Patients underwent a 36-hour SD procedure followed by nortriptyline started on the evening after SD, with ratings for two weeks. 2. Eleven (55%) patients were responders; they showed a rapid and sustained remission after SD, whereas non-responders demonstrated the delayed results expected with nortriptyline. 3. High initial depression scores and absence of depersonalization were associated with response to SD, while being female and middle insomnia were associated with response to the combined regimen. 4. The combination of SD with antidepressants proves to be an effective and safe treatment modality.

作者研究了完全睡眠剥夺（SD）联合去甲替林对20例重度抑郁症（MDD）患者的影响。患者先进行36小时的睡眠剥夺程序，之后在睡眠剥夺当晚开始服用去甲替林，并持续评估两周。2. 11名（55%）患者有反应；他们在睡眠剥夺后迅速且持续缓解，而无反应者则表现出与去甲替林预期相符的延迟效果。3. 初始抑郁评分高且不存在人格解体与对睡眠剥夺的反应相关，而女性和中度失眠与对联合治疗方案的反应相关。4. 睡眠剥夺与抗抑郁药联合使用被证明是一种有效且安全的治疗方式。

Shelton R C, Loosen P T

Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN.

Prog Neuropsychopharmacol Biol Psychiatry. 1993 Jan;17(1):113-23. doi: 10.1016/0278-5846(93)90036-r.

The authors examined the effect of total sleep deprivation (SD) in combination with nortriptyline in 20 patients with major depressive disorder (MDD). Patients underwent a 36-hour SD procedure followed by nortriptyline started on the evening after SD, with ratings for two weeks. 2. Eleven (55%) patients were responders; they showed a rapid and sustained remission after SD, whereas non-responders demonstrated the delayed results expected with nortriptyline. 3. High initial depression scores and absence of depersonalization were associated with response to SD, while being female and middle insomnia were associated with response to the combined regimen. 4. The combination of SD with antidepressants proves to be an effective and safe treatment modality.

作者研究了完全睡眠剥夺（SD）联合去甲替林对20例重度抑郁症（MDD）患者的影响。患者先进行36小时的睡眠剥夺程序，之后在睡眠剥夺当晚开始服用去甲替林，并持续评估两周。2. 11名（55%）患者有反应；他们在睡眠剥夺后迅速且持续缓解，而无反应者则表现出与去甲替林预期相符的延迟效果。3. 初始抑郁评分高且不存在人格解体与对睡眠剥夺的反应相关，而女性和中度失眠与对联合治疗方案的反应相关。4. 睡眠剥夺与抗抑郁药联合使用被证明是一种有效且安全的治疗方式。