Jost C M, Yancy C W, Ring W S
Department of Internal Medicine, UT Southwestern Medical Center, Dallas 75235-9034.
Ann Thorac Surg. 1993 Jan;55(1):159-61. doi: 10.1016/0003-4975(93)90497-6.
Prosthetic valve thrombosis is associated with high mortality. The treatment of choice remains operation. This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk. Combined thrombolytic therapy or therapy with a single agent with a long half-life and a prolonged infusion time is suggested as an emergent treatment option for prosthetic mitral valve thrombosis.
