McRae D, Buchanan G
Ear, Nose, and Throat Department, Southend Hospital, Westcliff-on-Sea, England.
Arch Otolaryngol Head Neck Surg. 1993 Jan;119(1):103-5. doi: 10.1001/archotol.1993.01880130105015.
Since 1985, a number of reports have highlighted the effectiveness of a short course of sulfamethoxazole-trimethoprim as an adjuvant to immunosuppressive drugs in the treatment of Wegener's granulomatosis. We report our experience with long-term sulfamethoxazole-trimethoprim therapy in patients with Wegener's granulomatosis. We describe recent advances in the pathogenesis of Wegener's granulomatosis, suggest a complementary mechanism of action of sulfamethoxazole-trimethoprim, and advocate long-term sulfamethoxazole-trimethoprim therapy as a treatment option in Wegener's granulomatosis.
