Jones M W, Silverberg S G, Kurman R J
Johns Hopkins Hospital, Baltimore, Maryland.
Int J Gynecol Pathol. 1993 Jan;12(1):1-7. doi: 10.1097/00004347-199301000-00001.
We reviewed the clinical and pathological features of 24 cases of well-differentiated villoglandular adenocarcinoma of the uterine cervix. The patients' ages ranged from 27 to 54 years, with an average age of 37. At least 15 patients were taking oral contraceptive prior to diagnosis, compared to five of 18 in a control group of patients with various other histologic types of cervical adenocarcinoma. All of the neoplasms were exophytic polypoid lesions with thick or thin papillae lined by endocervical, endometrial or intestinal-type epithelium showing mild cytologic atypia. Ten were associated with adenocarcinoma in situ, eight with cervical intraepithelial neoplasia, and one with microglandular hyperplasia. All tumors were confined to the cervix. Five patients were treated by excisional biopsy or cone biopsy, four by simple hysterectomy with prior or subsequent radiation therapy, and 15 by radical hysterectomy. All patients are alive and well, with no evidence of recurrent disease. The follow-up ranged from 7 to 77 months, with a mean of 36 months.
我们回顾了24例高分化宫颈绒毛腺管状腺癌的临床和病理特征。患者年龄在27至54岁之间，平均年龄为37岁。至少15例患者在诊断前服用口服避孕药，相比之下，18例其他组织学类型宫颈腺癌对照组患者中有5例服用。所有肿瘤均为外生性息肉样病变，有粗细不等的乳头，内衬宫颈内膜、子宫内膜或肠型上皮，显示轻度细胞学异型性。10例与原位腺癌相关，8例与宫颈上皮内瘤变相关，1例与微小腺体增生相关。所有肿瘤均局限于宫颈。5例患者接受了切除活检或锥形活检，4例接受了单纯子宫切除术，术前或术后接受了放疗，15例接受了根治性子宫切除术。所有患者均存活且状况良好，无复发疾病迹象。随访时间为7至77个月，平均36个月。
