采用半定量30分钟99m锝-甲氧基异丁基异腈甲状腺摄取法快速诊断甲状腺功能亢进症。
Quick diagnosis of hyperthyroidism with semiquantitative 30-minute technetium-99m-methoxy-isobutyl-isonitrile thyroid uptake.
作者信息
Kao C H, Wang S J, Liao S Q, Lin W Y, Hsu C Y
机构信息
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
出版信息
J Nucl Med. 1993 Jan;34(1):71-4.
Ten normal volunteers and 14 patients with hyperthyroidism had pinhole thyroid imaging 30 min after an intravenous injection of 10 mCi 99mTc-MIBI. Technetium-99m-MIBI thyroid uptake was calculated by the formula: [total counts with a region of interest (ROI) over the whole thyroid gland] divided by [(mean counts of every pixel in the neck soft tissue) x (total number of pixels in ROI over the whole thyroid gland)]. The results showed that the 30 min 99mTc-MIBI thyroid uptake ratios had positive relationships with the 24 hr 131I-thyroid uptake (r = 0.79), and that the patients with hyperthyroidism had significantly higher 30 min 99mTc-MIBI thyroid uptake than the normal volunteers (5.31 +/- 0.78 s.e.m. versus 2.35 +/- 0.14 s.e.m., p < 0.005 using the Mann-Whitney U-test). Technetium-99m-MIBI thyroid uptake may be useful for the rapid diagnosis of hyperthyroidism.
10名正常志愿者和14名甲状腺功能亢进患者在静脉注射10毫居里99m锝-甲氧基异丁基异腈（99mTc-MIBI）后30分钟进行了针孔甲状腺显像。99m锝-甲氧基异丁基异腈甲状腺摄取率通过以下公式计算：[整个甲状腺区域感兴趣区（ROI）的总计数]除以[颈部软组织中每个像素的平均计数×整个甲状腺ROI中的像素总数]。结果显示，99mTc-MIBI 30分钟甲状腺摄取率与24小时131碘甲状腺摄取率呈正相关（r = 0.79），且甲状腺功能亢进患者的99mTc-MIBI 30分钟甲状腺摄取率显著高于正常志愿者（分别为5.31±0.78标准误和2.35±0.14标准误，采用曼-惠特尼U检验，p < 0.005）。99m锝-甲氧基异丁基异腈甲状腺摄取可能有助于甲状腺功能亢进的快速诊断。
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