Goodnight S H
Department of Pathology, Oregon Health Sciences University, Portland 97201-3098.
Arch Pathol Lab Med. 1993 Jan;117(1):102-6.
The potentially beneficial effects of dietary fatty acids on vascular disease continues to generate intense clinical and investigative interest throughout the world. In particular, attention has focused on the highly unsaturated n-3 fatty acids found in marine and certain plant oils in the prevention of atherosclerosis and thrombosis. This article will review the impact of these fatty acids on vascular disease in epidemiologic studies, in animal models of atherosclerosis and vascular injury, and in human clinical trials of restenosis following angioplasty. Some of the more specific cellular effects of n-3 fatty acids will also be discussed. The data accumulated in the last 15 years suggest that additional prospective clinical trials of n-3 fatty acids in the prevention or treatment of vascular disease are warranted in humans.
膳食脂肪酸对血管疾病潜在的有益作用在全球范围内持续引发强烈的临床和研究兴趣。特别是，人们将注意力集中在海洋油类和某些植物油中发现的高度不饱和n-3脂肪酸在预防动脉粥样硬化和血栓形成方面的作用。本文将综述这些脂肪酸在流行病学研究、动脉粥样硬化和血管损伤动物模型以及血管成形术后再狭窄的人体临床试验中对血管疾病的影响。还将讨论n-3脂肪酸一些更具体的细胞效应。过去15年积累的数据表明，有必要在人体中针对n-3脂肪酸预防或治疗血管疾病开展更多前瞻性临床试验。
