Mindermann T, Landolt H, Langemann H, Gratzl O
Departement Forschung, Kantonsspital Basel.
Schweiz Rundsch Med Prax. 1993 Jan 5;82(1):9-11.
Microdialysis of the cerebral extracellular space (CES) provides information on the cortical metabolic state by measurement of the concentrations of metabolites and transmitters as well as of the extracellular pH. In trauma patients, this kind of monitoring should reveal damage from secondary cortical ischemia in an early, hopefully reversible state. The method further allows in vivo measurement of drug levels in the CES and investigation of their effect on metabolism. Although microdialysis has mainly been used experimentally, it is now beginning to be applied clinically. We report on our experience with both experimental and clinical work.
对大脑细胞外间隙（CES）进行微透析，通过测量代谢物、递质的浓度以及细胞外pH值，可提供有关皮质代谢状态的信息。对于创伤患者，这种监测应能在早期（有望处于可逆状态）发现继发性皮质缺血造成的损伤。该方法还能在体内测量CES中的药物水平，并研究其对代谢的影响。尽管微透析主要用于实验，但目前已开始应用于临床。我们报告了我们在实验和临床工作方面的经验。
