Cnattingius S, Forman M R, Berendes H W, Graubard B I, Isotalo L
Division of Epidemiology, Statistics and Preventive Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Am J Obstet Gynecol. 1993 Jan;168(1 Pt 1):16-21. doi: 10.1016/s0002-9378(12)90878-9.
The purpose of our study was to investigate the combined interactive effects of maternal age, parity, and smoking on pregnancy outcome.
This was a population-based Swedish study (n = 538,829).
Multiple logistic regression analysis showed that the smoking-related effect on the relative increase in the odds ratio of low birth weight and preterm delivery was significantly greater among multiparous patients than nulliparous; among multiparas, smoking increased the odds ratios for low birth weight and preterm delivery by 2.4 and 1.6; the corresponding relative increases in the odds ratios among nulliparas were 1.7 and 1.1, respectively. With advancing maternal age there was a smoking-related relative increase in the odds ratios for small-for-gestational-age births. Moreover, the age effect on the relative increase of low birth weight, preterm delivery, and small-for-gestational-age births was greater among nulliparas than multiparas.
Older smokers are at an especially high risk for small-for-gestational-age births, and parous smokers are at an especially high risk for low birth weight and preterm delivery.
我们研究的目的是调查产妇年龄、产次和吸烟对妊娠结局的综合交互作用。
这是一项基于瑞典人群的研究（n = 538,829）。
多元逻辑回归分析显示，多产患者中吸烟对低出生体重和早产比值比相对增加的影响显著大于初产患者；在多产患者中，吸烟使低出生体重和早产的比值比分别增加2.4和1.6；初产患者中相应的比值比相对增加分别为1.7和1.1。随着产妇年龄的增长，吸烟相关的小于胎龄儿出生比值比相对增加。此外，初产患者中年龄对低出生体重、早产和小于胎龄儿出生相对增加的影响大于多产患者。
年龄较大的吸烟者发生小于胎龄儿出生的风险特别高，经产妇吸烟者发生低出生体重和早产的风险特别高。
