Navarro C, Márquez M, Hernando L, Galvañ F, Zapatero L, Caravaca F
Epidemiology Department, Murcia Health Council, Spain.
Epidemiology. 1993 Jan;4(1):76-9. doi: 10.1097/00001648-199301000-00014.
We conducted a matched case-control study to assess the association between epidemic asthma and soybean sensitivity in Cartagena, Spain. In skin tests, 81% of the cases and no control subjects were positive to the commercial soybean allergen; 87% of the cases and 12% of the controls were positive to the prepared soybean allergen; and 69% of the cases and 6% of the controls showed high levels of specific immunoglobulin E antibodies (odds ratio = 10; 95% confidence interval = 1.4-433). The association remained strong after adjustment for total immunoglobulin E and for 28 other allergens. The results indicate that soybean sensitivity may be causing asthma epidemics in Cartagena.
我们开展了一项匹配病例对照研究，以评估西班牙卡塔赫纳流行性哮喘与大豆过敏之间的关联。在皮肤试验中，81%的病例对市售大豆过敏原呈阳性反应，而对照受试者均为阴性；87%的病例对制备的大豆过敏原呈阳性反应，12%的对照受试者呈阳性反应；69%的病例和6%的对照受试者显示特异性免疫球蛋白E抗体水平较高（比值比=10；95%置信区间=1.4-433）。在对总免疫球蛋白E和其他28种过敏原进行校正后，这种关联仍然很强。结果表明，大豆过敏可能是卡塔赫纳哮喘流行的病因。
