Port R, Curtis K, Inoue C, Briggs J, Seybold K
Department of Psychology, Slippery Rock University, PA 16057.
Brain Res Bull. 1993;30(1-2):41-4. doi: 10.1016/0361-9230(93)90037-c.
The present study evaluated the effects of bilateral hippocampal lesions on appetitive instrumental conditioning with delayed (5-s interval) reinforcement in rats. Acquisition of a bar press response was considerably slower than rates observed with immediate reinforcement; however, no significant differences between hippocampally lesioned and control groups were noted regarding training to criteria or ratio of responses to reinforcements. These results suggest that the hippocampus is not essential for the association of temporally discontinuous stimuli, and that deficits in other forms of associative learning, such as spatial cognition, must be mediated by the loss of other functions. Putative functions and underlying substrates are discussed for response modulation and sensory (cue relations) associations.
本研究评估了双侧海马损伤对大鼠延迟（5秒间隔）强化的食欲性工具性条件反射的影响。压杆反应的习得比即时强化观察到的速度要慢得多；然而，在达到标准训练或反应与强化的比率方面，海马损伤组和对照组之间没有显著差异。这些结果表明，海马体对于时间上不连续刺激的关联并非必不可少，并且其他形式的联想学习（如空间认知）中的缺陷必定是由其他功能的丧失所介导的。本文还讨论了反应调节和感觉（线索关系）关联的假定功能和潜在底物。
