Bel'man E L, Gordeev Ia Ia
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(2):201-4.
The effect of cyclophosphamid on the development of disseminated sclerosis was studied in 85 patients. For this purpose the authors used a special scale for the assessment of neurological expressions of the disease and the remote results of treatment. The effectiveness depended mainly on the degree of severity. Satisfactory results directly following treatment were attained in patients with light and middle degrees of disseminated sclerosis. A significant regress of pathological signs on behalf of the motor (28%), sensory (37%) spheres and cranial innervation (38%) was marked. The remote results (after 6--12 months) point to the absence of development of the process. The use of cyclophosphamides was accompanied by a drop in the level of gamma-globulins in the blood serum of patients with disseminated sclerosis.
在85例患者中研究了环磷酰胺对播散性硬化症发展的影响。为此，作者使用了一种特殊的量表来评估该疾病的神经学表现及治疗的远期效果。疗效主要取决于疾病的严重程度。轻度和中度播散性硬化症患者在治疗后直接取得了满意的效果。运动（28%）、感觉（37%）领域及颅神经支配（38%）的病理体征有显著消退。远期效果（6至12个月后）表明病情未再发展。使用环磷酰胺会使播散性硬化症患者血清中的γ球蛋白水平下降。
