Magnussen I, Hoedt-Rasmussen K
Acta Neurol Scand. 1977 Feb;55(2):131-6. doi: 10.1111/j.1600-0404.1977.tb05633.x.
The dose-effect relationship of intracarotid administered aminophylline on cerebral hemodynamics in man was investigated by means of an intraarterial 133Xenon injection method. A dose dependent vasoconstriction was clearly demonstrated. The maximum efficacy expressed as measured decreased in global cerebral blood flow was 21.9 per cent +/- 6.2 SD. Administration of as little as 1 mg aminophylline produced a measureable vasoconstriction.
采用动脉内注入133氙的方法,研究了颈动脉内注射氨茶碱对人体脑血流动力学的剂量效应关系。结果清楚地显示出剂量依赖性血管收缩。以全脑血流量测量值下降表示的最大效应为21.9%±6.2标准差。注射低至1毫克氨茶碱即可产生可测量的血管收缩。