在妊娠早期，14C-α-氨基异丁酸优先摄取至小鼠子宫组织中。

Preferential uptake of 14c-alpha-aminoisobuturic acid into mouse uterine tissue during early pregnancy.

作者信息

Lindqvist I, Nilsson O, Ronquist G

出版信息

Acta Physiol Scand. 1977 Jan;99(1):37-41. doi: 10.1111/j.1748-1716.1977.tb10349.x.

DOI:10.1111/j.1748-1716.1977.tb10349.x

Abstract

The uptake of 14C-AIB into uterine tissue and some other organs was studied during early implantation. Mice in experimentally delayed implantation were given estrogen and 14C-AIB at different time intervals. Mice in delayed implantation given only 14C-AIB displayed a low transport rate into the uterine tissue, comparable with that for the diaphragm muscle. However, if the estrogen injection preceeded that of the 14C-AIB by 4 to 8 h the transport capacity increased by a factor of at least 4 times while the uptake for the diaphargm muscle remained low. Under such conditions 14C-AIB-accumulation into uterine tissue was favoured for at least 4 h of in vivo incubation with the labeled amino acid.

摘要

在早期着床期间研究了子宫组织和其他一些器官对¹⁴C-α-氨基异丁酸（¹⁴C-AIB）的摄取情况。处于实验性延迟着床状态的小鼠在不同时间间隔给予雌激素和¹⁴C-AIB。仅给予¹⁴C-AIB的延迟着床小鼠显示其进入子宫组织的转运速率较低，与膈肌的转运速率相当。然而，如果雌激素注射比¹⁴C-AIB注射提前4至8小时，则转运能力至少增加4倍，而膈肌的摄取量仍然较低。在这种条件下，在体内与标记氨基酸孵育至少4小时有利于¹⁴C-AIB在子宫组织中的积累。