Thorup M, Fog R
Acta Psychiatr Scand. 1977 Feb;55(2):123-6. doi: 10.1111/j.1600-0447.1977.tb00148.x.
Eleven male, chronic schizophrenic, hospitalized patients, treated with a constant dose of clozapine (range 200-600 mg daily) as their only neuroleptic medication were studied for a long period of time (minimum 12 weeks). Wide variations in the plasma concentration of clozapine were found in different patients who received the same oral dose, as well as great changes from week to week in the individual patient given a constant dose. The plasma levels of clozapine appeared to have no correlation with either the clinical effect or the side effects. No differences with regard to coagulation factors were found between the patients and the controls.
对11名男性慢性精神分裂症住院患者进行了长期研究（至少12周），他们仅接受恒定剂量的氯氮平（每日剂量范围为200 - 600毫克）作为唯一的抗精神病药物治疗。研究发现，接受相同口服剂量的不同患者，其氯氮平血浆浓度存在很大差异，而且给予恒定剂量的个体患者每周的变化也很大。氯氮平的血浆水平似乎与临床疗效或副作用均无关联。患者与对照组在凝血因子方面未发现差异。
