Silver K, Andermann F
Department of Neurology and Neurosurgery, McGill University, Montréal, PQ, Canada.
Neurology. 1993 Jan;43(1):36-41. doi: 10.1212/wnl.43.1_part_1.36.
Alternating hemiplegia of childhood is a rare syndrome characterized by onset before 18 months of age of frequent attacks of alternating paralysis, transient ocular palsies, nystagmus, choreoathetosis, and autonomic dysfunction. We describe features of 10 patients followed for up to 27 years. The mechanism of alternating hemiplegia remains unknown but an association to migraine is suspected because of the strong family history of migraine and aura symptoms in some patients. We treated nine patients with flunarizine, a calcium channel blocker, for up to 5 years; they showed a reduction in duration of the hemiplegic attacks, but the episodes ceased completely in only one patient. With long-term follow-up, the persistent motor, movement, and cognitive deficits are more apparent. It is not certain if the flunarizine alters this course.
儿童交替性偏瘫是一种罕见的综合征，其特征为在18个月前发病，频繁出现交替性瘫痪发作、短暂性眼肌麻痹、眼球震颤、舞蹈手足徐动症和自主神经功能障碍。我们描述了随访长达27年的10例患者的特征。交替性偏瘫的发病机制尚不清楚，但由于一些患者有偏头痛的家族史和先兆症状，怀疑与偏头痛有关。我们用钙通道阻滞剂氟桂利嗪治疗了9例患者，长达5年；他们偏瘫发作的持续时间有所缩短，但仅1例患者发作完全停止。经过长期随访，持续性运动、活动和认知缺陷更为明显。氟桂利嗪是否改变了这一病程尚不确定。
