Bertó J M, López C, Pino J M, Ojeda J A, Marin J
Section of Allergy, Hospital Dr Peset, Valencia, Spain.
Ann Allergy. 1993 Jan;70(1):40-3.
Lung function and bronchial response to methacholine were studied in 47 young adults who had had childhood asthma, and after a period of 14-21 years, showed a different clinical evolution. At present, these subjects have been classified in four clinical groups: asymptomatic, rhinitic, asthmatic only due to exercise, and asthmatic. The same study was performed in 23 healthy individuals without personal histories of respiratory or allergic pathology. We found low spirometric basal values in both the asthmatic group (FEV1 and FEF25-75) and in the group with asthmatic responses to exercise (FEF25-75). No significant differences were found among asymptomatic, rhinitic, and control groups. While airway hyperreactivity was observed in patients who still had asthma, the bronchial response to methacholine in asymptomatic and rhinitic groups was not different from the control group. We conclude that both lung function and bronchial response to methacholine in most of the adults who had asthma in infancy and had been without asthmatic symptoms for many years are similar to those observed in the general population.
对47名患有儿童哮喘且经过14至21年出现不同临床演变的年轻人进行了肺功能和支气管对乙酰甲胆碱反应的研究。目前，这些受试者已被分为四个临床组：无症状组、鼻炎组、仅运动诱发哮喘组和哮喘组。对23名无呼吸或过敏病史的健康个体进行了同样的研究。我们发现哮喘组（FEV1和FEF25 - 75）以及运动诱发哮喘反应组（FEF25 - 75）的肺量计基础值较低。无症状组、鼻炎组和对照组之间未发现显著差异。虽然在仍患有哮喘的患者中观察到气道高反应性，但无症状组和鼻炎组对乙酰甲胆碱的支气管反应与对照组无差异。我们得出结论，大多数婴儿期患哮喘且多年无哮喘症状的成年人的肺功能和支气管对乙酰甲胆碱的反应与普通人群相似。
