转化生长因子β通过降低白细胞介素-1受体表达，对培养的兔关节软骨细胞发挥与白细胞介素-1β相反的作用。
Transforming growth factor beta exerts opposite effects from interleukin-1 beta on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression.
作者信息
Rédini F, Mauviel A, Pronost S, Loyau G, Pujol J P
机构信息
Laboratoire de Biochimie du Tissu Conjonctif, CHU Côte de Nacre, Caen, France.
出版信息
Arthritis Rheum. 1993 Jan;36(1):44-50. doi: 10.1002/art.1780360108.
OBJECTIVE
The aim of the study was to determine whether transforming growth factor beta (TGF beta) modulates the effects and the receptor expression of interleukin-1 (IL-1) in rabbit articular chondrocytes (RAC).
METHODS
Collagen, glycosaminoglycan, and collagenase production, together with 125I-labeled IL-1 binding, were analyzed in RAC cultures.
RESULTS
TGF beta reduced both IL-1 effects on matrix metabolism and IL-1 receptor expression.
CONCLUSION
TGF beta acts as an antagonist of the effects of IL-1 through down-regulation of its receptor expression.
目的
本研究旨在确定转化生长因子β（TGF-β）是否调节白细胞介素-1（IL-1）对兔关节软骨细胞（RAC）的作用及其受体表达。
方法
分析RAC培养物中的胶原蛋白、糖胺聚糖和胶原酶产生情况，以及125I标记的IL-1结合情况。
结果
TGF-β降低了IL-1对基质代谢的作用以及IL-1受体表达。
结论
TGF-β通过下调其受体表达而作为IL-1作用的拮抗剂。
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