Transforming growth factor beta exerts opposite effects from interleukin-1 beta on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression.

OBJECTIVE

The aim of the study was to determine whether transforming growth factor beta (TGF beta) modulates the effects and the receptor expression of interleukin-1 (IL-1) in rabbit articular chondrocytes (RAC).

METHODS

Collagen, glycosaminoglycan, and collagenase production, together with 125I-labeled IL-1 binding, were analyzed in RAC cultures.

RESULTS

TGF beta reduced both IL-1 effects on matrix metabolism and IL-1 receptor expression.

CONCLUSION

TGF beta acts as an antagonist of the effects of IL-1 through down-regulation of its receptor expression.