Arnold T S, Thye F W
Am J Clin Nutr. 1977 Mar;30(3):381-7. doi: 10.1093/ajcn/30.3.381.
Effects of an oral contraceptive on plasma growth hormone and glucose tolerance were studied in two strains of rats, Sprague-Dawley, a normal strain, and BHE, a carbohydrate-sensitive strain. Ethynyl estradiol and norgestrel, combined in a dose representative of the clinical preparation of Ovral were given for 21 days. Plasma growth hormone was measured following sodium pentobarbital stimulation. In both strains fasting blood glucose levels were unchanged following oral contraceptive therapy, however, a strain difference in response to a glucose load was found. With contraceptive steroid treatment, Sprague-Dawley rats developed an impaired tolerance to glucose during the latter part of the glucose tolerance test. BHE control animals had an abnormal response to a glucose load which improved with oral contraceptive therapy. No significant correlation between growth hormone changes and changes in glucose tolerance during contraceptive steroid treatment were observed. Both strains of rats receiving oral contraceptives gained less weight than their controls, however, the difference was statistically significant only in the Sprague-Dawley strain.
在两种品系的大鼠中研究了口服避孕药对血浆生长激素和葡萄糖耐量的影响，一种是正常品系的斯普拉格-道利大鼠，另一种是对碳水化合物敏感的BHE大鼠。给予按临床制剂奥炔诺孕酮剂量组合的炔雌醇和炔诺孕酮，持续21天。在戊巴比妥钠刺激后测量血浆生长激素。在两个品系中，口服避孕药治疗后空腹血糖水平均未改变，然而，发现对葡萄糖负荷的反应存在品系差异。在接受避孕类固醇治疗的情况下，斯普拉格-道利大鼠在葡萄糖耐量试验后期对葡萄糖的耐受性受损。BHE对照动物对葡萄糖负荷有异常反应，口服避孕药治疗后有所改善。在避孕类固醇治疗期间，未观察到生长激素变化与葡萄糖耐量变化之间存在显著相关性。接受口服避孕药的两个品系大鼠体重增加均少于其对照组，然而，差异仅在斯普拉格-道利品系中具有统计学意义。
