Hausmann L, Goebel K M, Zehner J
Schweiz Med Wochenschr. 1976 Oct 23;106(43):1470-4.
The growth hormone, insulin and blood glucose values were measured during a glucose tolerance test in 12 women before and after 3 months' use of a contraceptive of the sequential type (11 pills containing 0.05 mg D-norgestrel and 0.05 mg ethinylestradiol and 10 pills containing 0.125 mg D-norgestrel and 0.05 mg ethinylestradiol). Neither fasting blood glucose nor glucose tolerance are altered during administration of the contraceptive steroids. On the other hand, the reactive insulin level is significantly increased in comparison to the basal value, thus showing the signs of hyperinsulinemia. Both the gestagens and the estrogens appear to contribute to this disturbance of insulin secretion. Presumably the hyperinsulinemia is an expression of decreased sensitivity of the peripheral tissue to insulin. The growth hormone, a so-called insulin antagonist, is not responsible for the "insulin resistance" observed. The values measured by us after administration of the contraceptive do not significantly differ from the basal values.
在12名女性使用序贯型避孕药（11片含0.05mg炔诺孕酮和0.05mg炔雌醇，10片含0.125mg炔诺孕酮和0.05mg炔雌醇）3个月前后，于葡萄糖耐量试验期间测量了生长激素、胰岛素和血糖值。在服用避孕甾体激素期间，空腹血糖和葡萄糖耐量均未改变。另一方面，反应性胰岛素水平与基础值相比显著升高，从而显示出高胰岛素血症的迹象。孕激素和雌激素似乎都促成了这种胰岛素分泌紊乱。推测高胰岛素血症是外周组织对胰岛素敏感性降低的一种表现。生长激素，一种所谓的胰岛素拮抗剂，并非所观察到的“胰岛素抵抗”的原因。我们在服用避孕药后测得的值与基础值无显著差异。
