Spurrell M T, Creed F H
Department of Psychiatry, Manchester Royal Infirmary.
Br J Psychiatry. 1993 Jan;162:60-4. doi: 10.1192/bjp.162.1.60.
Lymphocyte response to stimulation with phytohaemagglutinin (PHA) was assessed in 11 patients with major depression and 8 subjects anticipating bereavement, in order to examine whether altered immune response (PHA stimulation index) was more closely related to depressed mood than to sleep and weight changes. No significant relationship was found between sleep or weight changes and immune response. Depression, measured using the HRSD (with and without sleep scores) and the BDI, was related differently in the two groups. For the depressed patients, increasing depression was associated with reduction in immune response; among those anticipating bereavement (with low depression scores), increasing depression was associated with enhanced immune response. A regression curve using data from both samples demonstrated an inverted 'U'-shaped curve relating immune response to mild and severe depressed states. The results of this study suggest a hypothesis that may explain previous discrepant results and which requires testing on more subjects.
为了研究免疫反应改变（植物血凝素刺激指数）与抑郁情绪的关系是否比与睡眠和体重变化的关系更为密切，我们评估了11名重度抑郁症患者和8名预期会经历丧亲之痛的受试者对植物血凝素（PHA）刺激的淋巴细胞反应。未发现睡眠或体重变化与免疫反应之间存在显著关系。使用HRSD（含和不含睡眠评分）和BDI测量的抑郁在两组中的表现有所不同。对于抑郁症患者，抑郁程度增加与免疫反应降低相关；在预期会经历丧亲之痛的人群中（抑郁评分较低），抑郁程度增加与免疫反应增强相关。使用两个样本的数据绘制的回归曲线显示，免疫反应与轻度和重度抑郁状态之间呈倒“U”形曲线关系。本研究结果提出了一个假设，该假设可能解释先前相互矛盾的结果，并且需要在更多受试者身上进行验证。
