Raff R F, Loughran T P, Graham T, Pepe M, Johnston B, Sale G E, Storb R
Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Exp Hematol. 1993 Feb;21(2):385-7.
Previous studies in mice and monkeys suggested that either splenic irradiation of splenectomy led to enhanced allogeneic marrow engraftment. These findings suggested that a population of radiation-resistant host cells involved in mediating marrow graft rejection are sequestered in the spleen. In this current study, the effect of splenectomy in dogs receiving 9.2 Gy total body irradiation (TBI) and unrelated dog leukocyte antigen (DLA)-nonidentical donor marrow grafts was studied. We found that splenectomy did not significantly change the incidence of graft failure as compared to that observed in previously and concurrently transplanted nonsplenectomized recipients.
先前对小鼠和猴子的研究表明，脾脏照射或脾切除术会导致同种异体骨髓植入增强。这些发现表明，参与介导骨髓移植排斥反应的一群辐射抗性宿主细胞被隔离在脾脏中。在本研究中，研究了脾切除术对接受9.2 Gy全身照射（TBI）和不相关犬白细胞抗原（DLA）不匹配供体骨髓移植的犬的影响。我们发现，与先前和同时移植的未行脾切除术的受者相比，脾切除术并未显著改变移植失败的发生率。
