Pera M, Cameron A J, Trastek V F, Carpenter H A, Zinsmeister A R
Section of General Thoracic Surgery, Mayo Clinic, Rochester, Minnesota.
Gastroenterology. 1993 Feb;104(2):510-3. doi: 10.1016/0016-5085(93)90420-h.
The aim of this study was to determine whether the incidence of adenocarcinoma of the esophagus and esophagogastric junction in a well-defined population was higher than previously recognized.
Clinical records and original histological slides from patients residing in Olmsted County, Minnesota, were reviewed and compared with a previous study in the same population.
The incidence of esophageal adenocarcinoma rose from 0.13 for 1935-1971 to 0.74 for 1974-1989, and the incidence of adenocarcinoma of the esophagogastric junction rose from 0.25 to 1.34 per 100,000 person-years. Histological review of preserved surgical specimens showed associated intestinal metaplasia (Barrett's esophagus) in 2 of 2 esophageal and in 5 of 9 esophagogastric adenocarcinomas.
The incidence of adenocarcinoma in each location increased five to sixfold compared with the earlier study. This increase could not be explained by improved diagnostic methods or classification changes. The association with Barrett's esophagus and the parallel increased incidence of cancer in each location is evidence that adenocarcinoma of the esophagus and of the esophagogastric junction are related disorders.
本研究的目的是确定在一个明确界定的人群中，食管腺癌和食管胃交界腺癌的发病率是否高于先前的认识。
回顾了明尼苏达州奥尔姆斯特德县居民的临床记录和原始组织学切片，并与该人群先前的一项研究进行了比较。
食管腺癌的发病率从1935 - 1971年的0.13上升至1974 - 1989年的0.74，食管胃交界腺癌的发病率从每10万人年0.25上升至1.34。对留存手术标本的组织学检查显示，2例食管腺癌中有2例、9例食管胃腺癌中有5例伴有肠化生（巴雷特食管）。
与早期研究相比，每个部位腺癌的发病率增加了五到六倍。这种增加无法用诊断方法的改进或分类变化来解释。与巴雷特食管的关联以及每个部位癌症发病率的平行上升证明，食管腺癌和食管胃交界腺癌是相关疾病。
