Refinetti R
Department of Psychology, College of William & Mary, Williamsburg, VA 23187.
Int J Biomed Comput. 1993 Jan;32(1):45-60. doi: 10.1016/0020-7101(93)90006-r.
This paper describes a general model of the mammalian circadian pacemaker with specific parameters for golden hamsters. The model successfully simulates free-runs in constant darkness and constant light, phase shifts induced by light pulses and entrainment and relative coordination under light-dark cycles. It also accounts for the recent findings that the amplitude of the phase response curve to light pulses is dependent on the free-running period of the animal and on the previous history of photic stimulation. Effects of non-photic stimuli on the circadian pacemaker are discussed.
本文描述了一种具有金黄仓鼠特定参数的哺乳动物昼夜节律起搏器的通用模型。该模型成功模拟了在持续黑暗和持续光照条件下的自由运行、光脉冲诱导的相位偏移以及在明暗周期下的同步和相对协调。它还解释了最近的研究发现，即对光脉冲的相位响应曲线的幅度取决于动物的自由运行周期和先前的光刺激历史。文中还讨论了非光刺激对昼夜节律起搏器的影响。
