MacGregor G A, Markandu N D, Roulston J E, Jones J C, de Wardener H E
Lancet. 1979 Feb 24;1(8113):397-400. doi: 10.1016/s0140-6736(79)90880-8.
Ten women with "idiopathic" edema had sodium and water retention and a rapid gain in weight when their accustomed intake of diuretics was suddenly stopped. The magnitude of these changes was directly related to the levels of plasma-rening activity before withdrawal of diuretics. Nine patients became edematous. Within 10 days of stopping diuretics, plasma-renin activity and urinary aldosterone excretion decreased to normal or below and within 20 days weight-gain and edema had subsided in seven patients. But the greatest gains in weight, in three patients, were sustained beyond 20 days. Nevertheless, a year later, two of these three patients were free of edema without the use of diuretics. Intermittent edema of unknown cause in most, if not all, otherwise healthy women seems to result from their use of diuretics, abetted in some patients by self-imposed flucuation of sodium and carbohydrate intake, and does not appear to be idiopathic.
十名患有“特发性”水肿的女性在突然停止服用她们常用的利尿剂时，出现了钠和水潴留以及体重迅速增加的情况。这些变化的程度与停用利尿剂前的血浆肾素活性水平直接相关。九名患者出现了水肿。在停止使用利尿剂后的10天内，血浆肾素活性和尿醛固酮排泄降至正常或低于正常水平，20天内，七名患者的体重增加和水肿消退。但有三名患者体重增加最多，持续超过了20天。然而，一年后，这三名患者中的两名在未使用利尿剂的情况下摆脱了水肿。大多数（如果不是全部）原本健康的女性出现的不明原因的间歇性水肿似乎是由她们使用利尿剂引起的，在一些患者中，自我控制的钠和碳水化合物摄入量波动也起到了辅助作用，而且似乎并非特发性的。
