Kaminska G M, Niederkorn J Y
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235-9057.
Invest Ophthalmol Vis Sci. 1993 Jan;34(1):222-30.
The present study considered the hypothesis that spontaneous neovascularization of the cornea of nude mice results from a local imbalance between angiogenic and anti-angiogenic factors.
The presence of angiogenic and anti-angiogenic factors was revealed by exchanging orthotopic corneal allografts between nude BALB/c mice and normal (hirsute) euthymic BALB/c mice and observing the presence, intensity, and degree of corneal neovascularization before and after grafting.
Avascular corneal grafts from normal BALB/c donors resisted neovascularization after grafting to spontaneously vascularized graft beds in nude mice. In contrast, spontaneously vascularized corneal grafts from nude mice remained vascularized over 2 mo after grafting to similar nude recipients. Although corneal grafts from nude donors stimulated neovascularization in normal BALB/c recipients, most of the vessels regressed by the 6th week post transplantation.
The results confirm that there is an imbalance between angiogenic and anti-angiogenic factors in the nude mouse cornea. The cornea of the nude mouse displays more angiogenic activity and less anti-angiogenic activity than that of the normal mouse. Most angiogenic activity of the nude mouse cornea appears to reside in the epithelium.
本研究探讨裸鼠角膜自发新生血管形成是由血管生成因子与抗血管生成因子之间的局部失衡所致这一假说。
通过在裸BALB/c小鼠与正常（有毛）胸腺正常的BALB/c小鼠之间交换原位角膜同种异体移植物，并观察移植前后角膜新生血管的存在、强度和程度，来揭示血管生成因子与抗血管生成因子的存在情况。
来自正常BALB/c供体的无血管角膜移植物移植到裸鼠自发血管化的移植床后能抵抗新生血管形成。相反，来自裸鼠的自发血管化角膜移植物移植到相似的裸鼠受体后，在2个月内仍保持血管化。尽管来自裸鼠供体的角膜移植物在正常BALB/c受体中刺激了新生血管形成，但大多数血管在移植后第6周消退。
结果证实裸鼠角膜中血管生成因子与抗血管生成因子之间存在失衡。与正常小鼠相比，裸鼠角膜表现出更多的血管生成活性和更少的抗血管生成活性。裸鼠角膜的大多数血管生成活性似乎存在于上皮中。
