Jynge P, Holten T, Oksendal A N
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, Norway.
Invest Radiol. 1993 Jan;28(1):20-5. doi: 10.1097/00004424-199301000-00007.
Three formulations of the nonionic dimer iodixanol (150/200/300 mg I/mL), made isotonic by the addition of NaCl (70/53/24 mM), were investigated regarding their potential for depressing cardiac contractility during coronary angiography. To maintain a stable cardiac function, the authors sought the requirements for the addition of a balanced amount of calcium (Ca).
Iodixanol 150, 200, and 300 mg I/mL were applied as a short-lasting bolus in isolated perfused rat hearts in the absence and presence of added Ca. The contractile function was assessed by measurement of changes in left ventricular developed pressure (LVDP).
A transient LVDP depression was markedly alleviated by adding 0.2 to 0.4 mM Ca and almost abolished by 0.4 to 0.9 mM. Ca higher than 0.9 mM led to unstable hearts and too-extensive Ca loading.
Caution should be used when adding Ca to iodixanol, particularly with sodium-calcium (Na-Ca) relationships. Appropriate Ca concentrations are probably 0.6 mM for iodixanol (150 mg I/mL); 0.4 to 0.6 mM for iodixanol (200 mg I/mL; and 0.4 mM for iodixanol (300 mg I/mL).
研究了三种非离子二聚体碘克沙醇制剂（150/200/300mg I/mL），通过添加氯化钠（70/53/24mM）使其等渗，探讨其在冠状动脉造影期间抑制心脏收缩力的可能性。为维持稳定的心功能，作者探寻添加适量钙（Ca）的要求。
在添加和不添加钙的情况下，将150、200和300mg I/mL的碘克沙醇作为短效推注剂应用于离体灌注大鼠心脏。通过测量左心室舒张末期压力（LVDP）的变化来评估收缩功能。
添加0.2至0.4mM的钙可显著减轻LVDP的短暂降低，而添加0.4至0.9mM的钙几乎可消除这种降低。高于0.9mM的钙会导致心脏不稳定和钙负荷过大。
向碘克沙醇中添加钙时应谨慎，尤其是考虑钠钙（Na-Ca）关系时。对于碘克沙醇（150mg I/mL），合适的钙浓度可能为0.6mM；对于碘克沙醇（200mg I/mL），为0.4至0.6mM；对于碘克沙醇（300mg I/mL），为0.4mM。
