Choi B I, Lee D H, Han M C
Department of Radiology, Seoul National University College of Medicine, Korea.
Invest Radiol. 1993 Jan;28(1):33-8. doi: 10.1097/00004424-199301000-00010.
To assess the potential of magnetic resonance imaging (MRI) for evaluating the evolution of tumor necrosis, the authors evaluated 28 VX2 carcinomas inoculated in the thigh muscles of rabbits.
MRI of VX2 carcinomas at 2.0 T was done with spin-echo technique 1 week (14 tumors) and 3 weeks (14 tumors) after the inoculation of tumor cells. T1- and T2-weighted images were obtained with 500/30 and 2,500/80 sequences; the authors also performed enhanced T1-weighted images with contrast medium. MRI and histopathologic findings were compared.
Enhanced T1-weighted images with gadolinium-DTPA (Gd-DTPA) (dimeglumine gadopentetate) could depict necrosis in almost all tumors (27/28) and were the most sensitive technique followed by T2- and T1-weighted images. T2-weighted images best permitted the evaluation of the characteristics of necrotic areas in VX2 carcinomas, followed by T1-weighted images with contrast enhancement, and unenhanced T1-weighted images. On T2-weighted images, low-intensity areas of necrotic areas correspond to areas of early necrosis, isointense areas corresponded to areas of intermediate necrosis, and high-intensity areas corresponded to the late phase of necrosis.
MRI is useful in depicting necrosis and characterizing different phases of necrosis in VX2 carcinomas.
为评估磁共振成像（MRI）在评估肿瘤坏死演变方面的潜力，作者对28只接种于兔大腿肌肉的VX2癌进行了评估。
在接种肿瘤细胞后1周（14个肿瘤）和3周（14个肿瘤），采用自旋回波技术在2.0 T下对VX2癌进行MRI检查。使用500/30和2500/80序列获取T1加权和T2加权图像；作者还使用造影剂进行了增强T1加权图像检查。比较了MRI和组织病理学结果。
钆喷酸葡胺（Gd-DTPA）（钆双胺）增强T1加权图像几乎可以显示所有肿瘤（27/28）中的坏死情况，是最敏感的技术，其次是T2加权和T1加权图像。T2加权图像最有助于评估VX2癌坏死区域的特征，其次是增强T1加权图像和未增强T1加权图像。在T2加权图像上，坏死区域的低强度区域对应早期坏死区域，等强度区域对应中期坏死区域，高强度区域对应坏死晚期。
MRI有助于显示VX2癌中的坏死情况并对坏死的不同阶段进行特征描述。
