兔热病的免疫疗法：一种与土拉弗朗西斯菌反应的单克隆抗体的特性
Immunotherapy of tularemia: characterization of a monoclonal antibody reactive with Francisella tularensis.
作者信息
Narayanan R B, Drabick J J, Williams J C, Fortier A H, Meltzer M S, Sadoff J C, Bolt C R, Nacy C A
机构信息
Department of Cellular Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20850.
出版信息
J Leukoc Biol. 1993 Jan;53(1):112-6. doi: 10.1002/jlb.53.1.112.
An IgM monoclonal antibody (mAb) recognized surface antigens specific to Francisella tularensis wild-type (Schu4) and live vaccine strain (LVS), and reacted with both in ELISA and slide agglutination tests. This mAb also reacted with LVS microorganisms in tissues of infected mice as assessed by an indirect fluorescence technique. Western blot analysis showed the mAb to react with antigens associated with F. tularensis LPS.
一种IgM单克隆抗体（mAb）识别土拉弗朗西斯菌野生型（Schu4）和活疫苗株（LVS）特有的表面抗原，并且在酶联免疫吸附测定（ELISA）和玻片凝集试验中均与这两种菌株发生反应。通过间接荧光技术评估发现，该单克隆抗体也与感染小鼠组织中的LVS微生物发生反应。蛋白质免疫印迹分析表明，该单克隆抗体与土拉弗朗西斯菌脂多糖（LPS）相关抗原发生反应。
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