• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Preparation of monoclonal antibodies for detection and identification of Francisella tularensis.用于检测和鉴定土拉弗朗西斯菌的单克隆抗体的制备。
Clin Vaccine Immunol. 2007 Jan;14(1):81-4. doi: 10.1128/CVI.00057-06. Epub 2006 Nov 22.
2
Production and partial characterization of hybridoma clones secreting monoclonal antibodies against Francisella tularensis.分泌抗土拉弗朗西斯菌单克隆抗体的杂交瘤克隆的制备及部分特性鉴定
Hybridoma. 1993 Apr;12(2):197-202. doi: 10.1089/hyb.1993.12.197.
3
Generation and characterization of hybridoma antibodies for immunotherapy of tularemia.用于兔热病免疫治疗的杂交瘤抗体的产生与特性分析
Immunol Lett. 2007 Oct 15;112(2):92-103. doi: 10.1016/j.imlet.2007.07.006. Epub 2007 Aug 8.
4
[The preventive activity of monoclonal antibodies specific to the lipopolysaccharide of Francisella tularensis].[针对土拉热弗朗西斯菌脂多糖的单克隆抗体的预防活性]
Zh Mikrobiol Epidemiol Immunobiol. 1992(9-10):67-70.
5
Immunotherapy of tularemia: characterization of a monoclonal antibody reactive with Francisella tularensis.兔热病的免疫疗法：一种与土拉弗朗西斯菌反应的单克隆抗体的特性
J Leukoc Biol. 1993 Jan;53(1):112-6. doi: 10.1002/jlb.53.1.112.
6
Detection of Francisella tularensis-specific antibodies in patients with tularemia by a novel competitive enzyme-linked immunosorbent assay.通过一种新型竞争酶联免疫吸附测定法检测兔热病患者中兔热弗朗西斯菌特异性抗体。
Clin Vaccine Immunol. 2013 Jan;20(1):9-16. doi: 10.1128/CVI.00516-12. Epub 2012 Oct 31.
7
Development of a novel sandwich immunoassay based on targeting recombinant Francisella outer membrane protein A for the diagnosis of tularemia.基于靶向重组弗朗西斯氏菌外膜蛋白 A 的新型夹心免疫分析法的土拉菌病诊断。
Front Cell Infect Microbiol. 2024 Aug 20;14:1455259. doi: 10.3389/fcimb.2024.1455259. eCollection 2024.
8
[The determination of the antigenic determinant of protective monoclonal antibodies specific to the Francisella tularensis lipopolysaccharide].
Zh Mikrobiol Epidemiol Immunobiol. 1993 Jan-Feb(1):83-8.
9
Immunoglobulin G subclass switching impacts sensitivity of an immunoassay targeting Francisella tularensis lipopolysaccharide.免疫球蛋白 G 亚类转换影响针对土拉弗朗西斯菌脂多糖的免疫测定法的敏感性。
PLoS One. 2018 Apr 9;13(4):e0195308. doi: 10.1371/journal.pone.0195308. eCollection 2018.
10
Francisella tularensis infection-derived monoclonal antibodies provide detection, protection, and therapy.土拉弗朗西斯菌感染衍生的单克隆抗体可用于检测、防护及治疗。
Clin Vaccine Immunol. 2009 Mar;16(3):414-22. doi: 10.1128/CVI.00362-08. Epub 2009 Jan 28.

引用本文的文献

1
Virulence of Subspecies Biovar and Phenotypic Change during Serial Passages on Artificial Media.人工培养基连续传代过程中生物变种亚种的毒力及表型变化
Microorganisms. 2020 Nov 27;8(12):1881. doi: 10.3390/microorganisms8121881.
2
Complete Genome Sequences of Two Strains of Francisella tularensis subsp. bv. japonica.两株土拉热弗朗西斯菌亚种日本变种的全基因组序列
Microbiol Resour Announc. 2020 Nov 5;9(45):e01127-20. doi: 10.1128/MRA.01127-20.
3
The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide.弗朗西斯氏土拉弗朗西斯菌 O 抗原非还原端单克隆抗体的结合位点主要容纳末端糖。
Immunology. 2013 Nov;140(3):374-89. doi: 10.1111/imm.12150.
4
Detection of Francisella tularensis-specific antibodies in patients with tularemia by a novel competitive enzyme-linked immunosorbent assay.通过一种新型竞争酶联免疫吸附测定法检测兔热病患者中兔热弗朗西斯菌特异性抗体。
Clin Vaccine Immunol. 2013 Jan;20(1):9-16. doi: 10.1128/CVI.00516-12. Epub 2012 Oct 31.
5
Characterization of monoclonal antibodies to terminal and internal O-antigen epitopes of Francisella tularensis lipopolysaccharide.针对土拉弗朗西斯菌脂多糖末端和内部O抗原表位的单克隆抗体的特性分析
Hybridoma (Larchmt). 2011 Feb;30(1):19-28. doi: 10.1089/hyb.2010.0083.
6
Generation and characterization of hybridoma antibodies for immunotherapy of tularemia.用于兔热病免疫治疗的杂交瘤抗体的产生与特性分析
Immunol Lett. 2007 Oct 15;112(2):92-103. doi: 10.1016/j.imlet.2007.07.006. Epub 2007 Aug 8.

本文引用的文献

1
Detection of diverse new Francisella-like bacteria in environmental samples.在环境样本中检测多种新型类弗朗西斯菌属细菌。
Appl Environ Microbiol. 2005 Sep;71(9):5494-500. doi: 10.1128/AEM.71.9.5494-5500.2005.
2
Francisella tularensis enters macrophages via a novel process involving pseudopod loops.土拉弗朗西斯菌通过一种涉及伪足环的新过程进入巨噬细胞。
Infect Immun. 2005 Sep;73(9):5892-902. doi: 10.1128/IAI.73.9.5892-5902.2005.
3
A novel screening ELISA and a confirmatory Western blot useful for diagnosis and epidemiological studies of tularemia.一种用于兔热病诊断和流行病学研究的新型筛查酶联免疫吸附测定法（ELISA）及确证性蛋白质印迹法。
Epidemiol Infect. 2005 Aug;133(4):759-66. doi: 10.1017/s0950268805003742.
4
Tularemia: emergence/re-emergence.兔热病：新发/再发
Vet Res. 2005 May-Jun;36(3):455-67. doi: 10.1051/vetres:2005006.
5
Use of monoclonal antibodies for analyses of Coxiella burnetii major antigens.单克隆抗体在伯氏考克斯氏体主要抗原分析中的应用。
J Vet Med Sci. 2004 Oct;66(10):1289-91. doi: 10.1292/jvms.66.1289.
6
An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cells.兼性胞内细菌土拉弗朗西斯菌的减毒株可逃离单核细胞的吞噬体。
Infect Immun. 2003 Oct;71(10):5940-50. doi: 10.1128/IAI.71.10.5940-5950.2003.
7
Characterization of a novicida-like subspecies of Francisella tularensis isolated in Australia.在澳大利亚分离出的土拉热弗朗西斯菌诺维奇达样亚种的特征描述。
J Med Microbiol. 2003 Sep;52(Pt 9):839-842. doi: 10.1099/jmm.0.05245-0.
8
Survival and growth of Francisella tularensis in Acanthamoeba castellanii.土拉弗朗西斯菌在卡氏棘阿米巴中存活及生长情况
Appl Environ Microbiol. 2003 Jan;69(1):600-6. doi: 10.1128/AEM.69.1.600-606.2003.
9
Tularemia.兔热病
Clin Microbiol Rev. 2002 Oct;15(4):631-46. doi: 10.1128/CMR.15.4.631-646.2002.
10
Mapping of immunoreactive antigens of Francisella tularensis live vaccine strain.图拉弗朗西斯菌活疫苗株免疫反应性抗原的定位
Proteomics. 2002 Jul;2(7):857-67. doi: 10.1002/1615-9861(200207)2:7<857::AID-PROT857>3.0.CO;2-L.

用于检测和鉴定土拉弗朗西斯菌的单克隆抗体的制备。

Preparation of monoclonal antibodies for detection and identification of Francisella tularensis.

作者信息

Hotta Akitoyo, Uda Akihiko, Fujita Osamu, Tanabayashi Kiyoshi, Yamada Akio

机构信息

Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Tokyo 162-8640, Japan.

出版信息

Clin Vaccine Immunol. 2007 Jan;14(1):81-4. doi: 10.1128/CVI.00057-06. Epub 2006 Nov 22.

DOI:10.1128/CVI.00057-06
PMID:17121981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1797713/
Abstract

Monoclonal antibodies (MAbs) against Francisella tularensis were obtained. Three MAbs specifically reacted with F. tularensis, while four MAbs reacted with other members of the genus Francisella as well. Fluorescent isothiocyanate-conjugated MAbs unequivocally stained bacterial cells in specimens from experimentally infected mice. Two MAbs agglutinated F. tularensis antigen in the agglutination tests. These MAbs should improve methods for detection and identification of F. tularensis.

摘要

获得了针对土拉弗朗西斯菌的单克隆抗体（MAbs）。三种单克隆抗体与土拉弗朗西斯菌特异性反应，而另外四种单克隆抗体也与弗朗西斯菌属的其他成员反应。异硫氰酸荧光素偶联的单克隆抗体明确地对实验感染小鼠标本中的细菌细胞进行了染色。两种单克隆抗体在凝集试验中凝集了土拉弗朗西斯菌抗原。这些单克隆抗体应能改进土拉弗朗西斯菌的检测和鉴定方法。