Lin T M, Evans D C, Chance R E, Spray G F
Am J Physiol. 1977 Mar;232(3):E311-5. doi: 10.1152/ajpendo.1977.232.3.E311.
Bovine pancreatic peptide (BPP) is a straight chain peptide containing 36 amino acid residues that has recently been isolated from pancreatic tissue. At a dose of 40 mug/kg-h intravenously, it stimulated gastric acid secretion when given alone but inhibited the submaximal secretion induced by the C-terminal pentapeptide of gastrin. Basal pancreatic secretion of dogs was inhibited by BPP (1-10 mug/kg-h) inhibited pancreatic protein secretion but often showed a biphasic action on water-bicarbonate response, an initial augmentation followed by reduction. BPP (2-5 mug/kg-h) inhibited pancreatic water-bicarbonate and protein secretions induced by an infusion of secretin plus cholecystokinin. Des-tyrosyl-NH2 BPP lacking the C-terminal tyrosyl amide, failed to inhibit gastric acid induced by C-terminal pentapeptide of gastrin or pancreatic secretion induced by secretin. BPP had no hyper- or hypoglycemic, hyperkalemic, or diuretic actions in the dog.
牛胰肽（BPP）是一种含有36个氨基酸残基的直链肽，最近从胰腺组织中分离出来。静脉注射剂量为40微克/千克·小时时，单独给药可刺激胃酸分泌，但可抑制胃泌素C末端五肽诱导的次最大分泌。BPP（1 - 10微克/千克·小时）可抑制犬的基础胰腺分泌，抑制胰腺蛋白质分泌，但对水 - 碳酸氢盐反应常表现出双相作用，先是增强，随后减弱。BPP（2 - 5微克/千克·小时）可抑制由促胰液素加胆囊收缩素输注诱导的胰腺水 - 碳酸氢盐和蛋白质分泌。缺乏C末端酪氨酰胺的去酪氨酰 - NH2 BPP不能抑制胃泌素C末端五肽诱导的胃酸分泌或促胰液素诱导的胰腺分泌。BPP对犬没有升血糖或降血糖、高钾血症或利尿作用。
