Meisel A D, Diamond H S
Am J Physiol. 1977 Mar;232(3):F222-6. doi: 10.1152/ajprenal.1977.232.3.F222.
Both para-aminohippurate (PAH) and pyrazinamide inhibited the uricosuric response to probenecid administration. The mechanism of this inhibition of probenecid uricosuria was assessed in 18 male subjects. The decrease in uricosuria was assessed in 18 male subjects. The decrease in uricosuric response to probenecid observed after pyrazinamide administration or PAH infusion occurs by different mechanisms. Administration of PAH and probenecid together resulted in reduced excretion of both drugs. PAH was weakly uricosuric and did not appear to inhibit urate secretion. PAH inhibition of probenecid uricosuria is accounted for by inhibition of probenecid secretion. Probenecid excretion was not affected by pyrazinamide administration. Inhibition of probenecid-induced uricosuria by pyrazinamide is most likely due to inhibition of urate secretion. The urate secretory carrier inhibited by pyrazinamide appears to be independent of that responsible for secretion of probenecid and PAH. Probenecid secretion appears to be required for its uricosuric effect.
对氨基马尿酸（PAH）和吡嗪酰胺均抑制了给予丙磺舒后的尿酸排泄增加反应。在18名男性受试者中评估了这种对丙磺舒尿酸排泄增加抑制作用的机制。在18名男性受试者中评估了尿酸排泄的减少情况。给予吡嗪酰胺或输注PAH后观察到的对丙磺舒尿酸排泄增加反应的降低是由不同机制引起的。同时给予PAH和丙磺舒导致两种药物的排泄减少。PAH有微弱的促尿酸排泄作用，且似乎不抑制尿酸分泌。PAH对丙磺舒尿酸排泄增加的抑制作用是由于对丙磺舒分泌的抑制。丙磺舒的排泄不受给予吡嗪酰胺的影响。吡嗪酰胺对丙磺舒诱导的尿酸排泄增加的抑制作用很可能是由于对尿酸分泌的抑制。被吡嗪酰胺抑制的尿酸分泌载体似乎独立于负责丙磺舒和PAH分泌的载体。丙磺舒的分泌似乎是其促尿酸排泄作用所必需的。
