健康受试者和患病患者胼胝体的矢状面磁共振测量：一项前瞻性调查。
Midsagittal MR measurements of the corpus callosum in healthy subjects and diseased patients: a prospective survey.
作者信息
Laissy J P, Patrux B, Duchateau C, Hannequin D, Hugonet P, Ait-Yahia H, Thiebot J
机构信息
Department of Radiology, Bichat University Hospital, Paris, France.
出版信息
AJNR Am J Neuroradiol. 1993 Jan-Feb;14(1):145-54.
PURPOSE
To determine quantitatively a possible corpus callosum (CC) involvement in normal aging and white matter diseases.
METHODS
Midsagittal size and signal of CC were recorded prospectively from 243 routine MR brain examinations. A midline internal skull surface (MISS) and subcutaneous fat signal intensity were measured to calculate CC/MISS and CC/fat ratios. Four groups of subjects were studied: 124 apparently healthy subjects, 45 patients with multiple sclerosis, 13 patients with a noncerebral cancer under chemotherapy, and 37 AIDS patients.
RESULTS
Mean surface area of CC in controls was 6.36 cm2. It was significantly larger in men than in women (P < .05), but CC/MISS ratio was not. Elderly controls > 70 years and AIDS patients displayed significant CC atrophy, as well as multiple sclerosis subjects with long-standing disease or with a severe chronic progressive form.
CONCLUSION
CC substance loss identification should not be based on visual inspection or on absolute area, but by means of a CC/MISS ratio.
目的
定量确定胼胝体（CC）在正常衰老和白质疾病中的可能受累情况。
方法
前瞻性记录243例常规脑部磁共振成像（MR）检查中CC的矢状面大小和信号。测量中线颅骨内表面（MISS）和皮下脂肪信号强度，以计算CC/MISS和CC/脂肪比率。研究了四组受试者：124例明显健康的受试者、45例多发性硬化症患者、13例接受化疗的非脑癌患者和37例艾滋病患者。
结果
对照组CC的平均表面积为6.36平方厘米。男性明显大于女性（P <.05），但CC/MISS比率无差异。70岁以上的老年对照组和艾滋病患者以及患有长期疾病或严重慢性进行性形式的多发性硬化症患者表现出明显的CC萎缩。
结论
CC物质损失的识别不应基于视觉检查或绝对面积，而应通过CC/MISS比率来确定。
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