Simon J H, Schiffer R B, Rudick R A, Herndon R M
AJNR Am J Neuroradiol. 1987 Jul-Aug;8(4):599-604.
To quantitate the extent of corpus callosum atrophy in multiple sclerosis, midsagittal corpus callosum areas were determined in 48 controls with normal MR scans and 41 patients with definite multiple sclerosis. The mean midsagittal corpus callosum area was 601 mm2 (range 405-791), 641 mm2, and 561 mm2 for all adult controls, for adult males, and for adult females, respectively. Control values were significantly greater than the means determined for all multiple sclerosis (MS) patients (508 mm2, range 281-758), for MS men (528 mm2), or for MS women (498 mm2). The degree of corpus callosum atrophy paralleled the estimated volume of periventricular and corpus callosum high-signal lesions, suggesting a possible cause-effect relationship. The results indicate that corpus callosum atrophy occurs commonly in patients with typical clinical forms of multiple sclerosis.
为了量化多发性硬化症中胼胝体萎缩的程度，对48例磁共振成像（MR）扫描正常的对照者和41例确诊为多发性硬化症的患者测定了矢状位胼胝体面积。所有成年对照者、成年男性和成年女性的平均矢状位胼胝体面积分别为601平方毫米（范围405 - 791）、641平方毫米和561平方毫米。对照值显著高于所有多发性硬化症（MS）患者（508平方毫米，范围281 - 758）、MS男性（528平方毫米）或MS女性（498平方毫米）的测定均值。胼胝体萎缩程度与脑室周围及胼胝体高信号病变的估计体积平行，提示可能存在因果关系。结果表明，胼胝体萎缩常见于典型临床类型的多发性硬化症患者。
