Moore G E, Hoenig M
Department of Physiology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Am J Vet Res. 1993 Jan;54(1):126-9.
Prednisone was administered orally for 4 weeks at a dosage of 1.1 mg/kg of body weight/d, in divided dose every 12 hours, to a group of healthy adult dogs (n = 12). Intravenous glucose tolerance testing was performed before and after the 28-day regimen in each dog, as well as in dogs of a control group (n = 6). Glucose metabolism was evaluated by measurement of preprandial plasma insulin and glucose concentrations, total insulin secretion, and fractional clearance of glucose. Mean preprandial plasma insulin and glucose concentrations were not increased after the 4-week regimen of prednisone. Total insulin secretion in response to an IV administered glucose load was not increased in treated dogs, compared with pretreatment values or with values for control dogs. The fractional clearance of glucose was also not altered in dogs given prednisone. Results indicate that anti-inflammatory doses of prednisone, given orally for 4 weeks, probably do not alter insulin sensitivity or glucose tolerance in clinically normal dogs.
给一组健康成年犬（n = 12）口服泼尼松4周，剂量为1.1毫克/千克体重/天，每12小时分剂量给药。在每组犬28天疗程前后以及对照组犬（n = 6）中进行静脉葡萄糖耐量试验。通过测量餐前血浆胰岛素和葡萄糖浓度、总胰岛素分泌以及葡萄糖的分数清除率来评估葡萄糖代谢。泼尼松4周疗程后，平均餐前血浆胰岛素和葡萄糖浓度未升高。与治疗前值或对照犬的值相比，接受治疗的犬对静脉注射葡萄糖负荷的总胰岛素分泌未增加。给予泼尼松的犬中葡萄糖的分数清除率也未改变。结果表明，口服抗炎剂量的泼尼松4周，可能不会改变临床正常犬的胰岛素敏感性或葡萄糖耐量。
