Zinkernagel R M, Hengartner H
Institute of Experimental Immunology, University of Zurich, Switzerland.
Int Arch Allergy Immunol. 1993;100(1):8-11. doi: 10.1159/000236380.
This commentary argues that conventional antiviral cytotoxic T cells act suppressively by eliminating antigen-presenting cells, sometimes including lymphocytes, T or B cells expressing relevant antigens of exogenous or endogenous, most commonly of viral origin. They thereby limit expression of antigens, and by eliminating the antigen-expressing cells stop immune responses. However, to argue that induced T cells (or antibodies) function to eliminate or neutralize antigen is the shortest summary of immunology and neither new nor heretic.
本评论认为,传统的抗病毒细胞毒性T细胞通过消除抗原呈递细胞发挥抑制作用,这些细胞有时包括淋巴细胞、表达外源性或内源性相关抗原(最常见为病毒来源)的T细胞或B细胞。它们从而限制抗原的表达,并通过消除表达抗原的细胞来终止免疫反应。然而,认为诱导性T细胞(或抗体)的功能是消除或中和抗原,这是对免疫学的最短概括,既不新颖也非异端邪说。