羟钴胺对大鼠主动脉和肛门尾骨肌中一氧化氮介导的舒张作用的差异影响。
Differential effects of hydroxocobalamin on NO-mediated relaxations in rat aorta and anococcygeus muscle.
作者信息
Rajanayagam M A, Li C G, Rand M J
机构信息
Department of Pharmacology, University of Melbourne, Victoria, Australia.
出版信息
Br J Pharmacol. 1993 Jan;108(1):3-5. doi: 10.1111/j.1476-5381.1993.tb13429.x.
Abstract
In rat aortic rings, hydroxocobalamin (10-30 microM) produced concentration-dependent reductions of the relaxant action of nitric oxide (NO) and the endothelium-dependent, NO-mediated, relaxant action of acetylcholine. In anococcygeus muscles, hydroxocobalamin (10-30 microM) reduced but also prolonged, NO-induced relaxations, but had no effect on non-adrenergic, non-cholinergic-mediated relaxations. Hydroxocobalamin had no effect on the NO-independent relaxant action of papaverine in either tissue. It is suggested that hydroxocobalamin sequesters NO by forming nitrosocobalamin. Nitrosocobalamin did not relax aortic rings, but produced a slowly developing and prolonged relaxation of anococcygeus muscles.
摘要
在大鼠主动脉环中，羟钴胺素（10 - 30微摩尔）使一氧化氮（NO）的舒张作用以及乙酰胆碱的内皮依赖性、NO介导的舒张作用呈浓度依赖性降低。在肛门尾骨肌中，羟钴胺素（10 - 30微摩尔）降低但也延长了NO诱导的舒张，对非肾上腺素能、非胆碱能介导的舒张无影响。羟钴胺素对两种组织中罂粟碱的非NO依赖性舒张作用均无影响。提示羟钴胺素通过形成亚硝酰钴胺素来螯合NO。亚硝酰钴胺素不会使主动脉环舒张，但会使肛门尾骨肌产生缓慢发展且持久的舒张。
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