Zhang L, Dyer D C
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Iowa State University, Ames 50011.
Eur J Pharmacol. 1993 Jan 5;230(1):115-7. doi: 10.1016/0014-2999(93)90420-m.
d-Lysergic acid diethylamide (LSD) produced dose-dependent contractions (EC50, 17.9 +/- 2.1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin. The maximal contraction to LSD was 51% of the 5-HT response. LSD competitively antagonized (pA2 9.21) contractions produced to 5-hydroxytryptamine (5-HT). The results indicate that LSD is a partial agonist at 5-HT2 receptors in ovine uterine artery.
d-麦角酸二乙酰胺（LSD）对妊娠晚期绵羊离体子宫动脉产生剂量依赖性收缩（半数有效浓度[EC50]，17.9±2.1纳摩尔），酮色林可对其产生竞争性拮抗作用。LSD引起的最大收缩幅度为5-羟色胺（5-HT）反应的51%。LSD对5-羟色胺（5-HT）引起的收缩产生竞争性拮抗作用（拮抗常数[pA2]为9.21）。结果表明，LSD是绵羊子宫动脉5-HT2受体的部分激动剂。
