Minoshima S, Koeppe R A, Mintun M A, Berger K L, Taylor S F, Frey K A, Kuhl D E
Department of Internal Medicine, University of Michigan, Ann Arbor.
J Nucl Med. 1993 Feb;34(2):322-9.
A technique has been developed for automated detection of the intercommissural (AC-PC) line for positron emission tomography (PET). The AC-PC line is estimated from the location of four internal landmarks; the frontal and occipital poles, the inferior aspect of the anterior corpus callosum, and the subthalamic point. The landmarks are detected automatically in PET mid-sagittal slices by combining edge detection, interpolation and profile curve analysis techniques. The anatomical relationships between the true and estimated AC-PC lines from the landmarks was confirmed by analysis of magnetic resonance (MR) images. Accuracy of the automated estimation technique was assessed in co-registered PET and MR images, which showed minimal angular differences and displacements of the estimated from the true AC-PC lines. The automated detection of the AC-PC line in a PET study enables accurate stereotactic localization of functional signals without the need for additional anatomical imaging and provides a basis for objective and reproducible intersubject comparison.
已开发出一种用于正电子发射断层扫描（PET）的自动检测连合间（AC-PC）线的技术。AC-PC线是根据四个内部标志点的位置估计得出的；额极和枕极、胼胝体前部的下侧以及丘脑下点。通过结合边缘检测、插值和轮廓曲线分析技术，在PET正中矢状切片中自动检测这些标志点。通过对磁共振（MR）图像的分析，证实了由标志点得出的真实AC-PC线与估计的AC-PC线之间的解剖关系。在配准的PET和MR图像中评估了自动估计技术的准确性，结果显示估计的AC-PC线与真实的AC-PC线之间的角度差异和位移极小。在PET研究中自动检测AC-PC线能够在无需额外解剖成像的情况下对功能信号进行精确的立体定位，并为客观且可重复的受试者间比较提供了基础。
