Worsey M J, Laborde A L, Miller B V, Bower T R, Landas S, Kresowik T K, Sharp W J, Hoballah J, Corson J D
Department of Surgery, University of Iowa College of Medicine, Iowa City 52242.
J Surg Res. 1993 Jan;54(1):29-33. doi: 10.1006/jsre.1993.1005.
The healing characteristics and morphological features of a trans-anastomotic endovascular multifilament flexible metallic stent (Wallstent, Schneider) were investigated in a canine end-to-end arterial model. Both femoral arteries of 12 conditioned mongrel dogs were exposed, then transversely divided and reanastomosed. One anastomosis was randomly chosen for stent placement. Stents were chosen to match the diameter of the femoral arteries and were 25 mm in unconstrained length. Animals were sacrificed at intervals of 3, 6, 9, and 12 weeks. The anastomotic segments were pressure perfusion fixed and sectioned. The cross-sectional luminal, intimal, and medial areas were calculated from computer digitized images of the individual sections. Data were analyzed by univariate repeated measures analysis of variance. Stented anastomoses had an increased luminal area as compared with the anastomosis of non stented sections (P < 0.002). However, stended segments had a significantly increased intimal area when compared to control segments in the same animal (P < 0.001). Stented anastomoses had a significantly increased lumen area over controls despite a marked intimal response to the stent.
在犬端端动脉模型中研究了经吻合口血管内多丝柔性金属支架（Wallstent，施奈德公司）的愈合特性和形态学特征。暴露12只经训练的杂种犬的双侧股动脉，然后横向切断并重新吻合。随机选择一个吻合口进行支架置入。选择与股动脉直径匹配的支架，其无约束长度为25毫米。在3、6、9和12周的间隔时间处死动物。对吻合段进行压力灌注固定并切片。从各切片的计算机数字化图像计算横截面管腔、内膜和中膜面积。数据采用单变量重复测量方差分析进行分析。与未置入支架段的吻合口相比，置入支架的吻合口管腔面积增加（P<0.002）。然而，与同一动物的对照段相比，置入支架段的内膜面积显著增加（P<0.001）。尽管对支架有明显的内膜反应，但置入支架的吻合口管腔面积仍比对照显著增加。
