Nakase K, Kita K, Otsuji A, Anazawa H, Shirakawa S, Nasu K, Dohy H, Tsutani H, Tanaka I
Department of Internal Medicine, Yamada Red Cross Hospital, Misono, Japan.
Leuk Res. 1993 Jan;17(1):17-21. doi: 10.1016/0145-2126(93)90136-9.
Leukemic cells from 21 to 197 adult patients with de novo acute myelocytic leukemia (AML) were positive for IL-2R alpha chain (IL-2R alpha), whereas IL-2R beta chain (IL-2R beta), which is responsible for IL-2 signal transduction, was not found on leukemic cells from any of these cases tested. The expression of IL-2R alpha was closely associated with that of adhesion molecules CD4, CD11b and CD22, and endopeptidase CD10. None of the IL-2R alpha (+) AML cells responded to recombinant human IL-2. These data suggest that IL-2R alpha on AML cells may not be involved in cellular proliferation as one of growth factor receptors but may have a role in the control of cell-to-cell interactions.
21至197例成年初发急性髓细胞白血病（AML）患者的白血病细胞表达白细胞介素2α链（IL-2Rα），而负责IL-2信号转导的白细胞介素2β链（IL-2Rβ）在所有这些检测病例的白血病细胞中均未发现。IL-2Rα的表达与黏附分子CD4、CD11b和CD22以及内肽酶CD10的表达密切相关。IL-2Rα（+）的AML细胞对重组人IL-2均无反应。这些数据表明，AML细胞上的IL-2Rα可能不作为生长因子受体参与细胞增殖，但可能在细胞间相互作用的调控中发挥作用。
