Harnes D K, Thune P
Hudavdelingen, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1993 Jan 20;113(2):200-1.
Photochemotherapy with psoralens + ultraviolet (UV)-A light (PUVA) has been used for about 16 years to treat psoriasis. Some reports have indicated a higher frequency of cutaneous squamous cell carcinoma among treated patients. The results are not consistent, however, and are not generally conceded. Our material from Ullevål Hospital comprises 585 patients who have been treated with PUVA from 1977 until 1991. Three patients developed cutaneous squamous cell carcinoma, but in one of them the tumour developed before start of PUVA treatment. The two others had received only very small doses. One of them had an intraepithelial cancer of the penis. In addition we registered various internal cancers in 25 patients. The Norwegian Cancer Registry compared our patient materiel with a matched control group as regards sex, age and age-specific incidence rate. There was no statistically significant difference in incidence between the patient and the control group.
补骨脂素与紫外线A光（PUVA）联合进行的光化学疗法已用于治疗银屑病约16年。一些报告指出，接受治疗的患者中皮肤鳞状细胞癌的发生率较高。然而，结果并不一致，也未得到普遍认可。我们来自于勒沃尔医院的资料包括1977年至1991年期间接受PUVA治疗的585例患者。3例患者发生了皮肤鳞状细胞癌，但其中1例肿瘤在PUVA治疗开始前就已出现。另外2例仅接受了非常小的剂量。其中1例患有阴茎上皮内癌。此外，我们在25例患者中记录了各种内部癌症。挪威癌症登记处就性别、年龄和年龄特异性发病率将我们的患者资料与一个匹配的对照组进行了比较。患者组和对照组之间的发病率没有统计学上的显著差异。
