• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The toxicological effect of cyclophosphamide on acetylcholinesterase activity.

作者信息

al-Jafari A A

机构信息

Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.

出版信息

Toxicol Lett. 1993 Feb;66(2):125-31. doi: 10.1016/0378-4274(93)90087-e.

DOI:10.1016/0378-4274(93)90087-e
PMID:8430432
Abstract

Cyclophosphamide (CP; 2.5-10.0 mM) reversibly inhibits acetylcholinesterase (AChE) activity of chicken brain (58-84%) in a concentration-dependent manner, the IC50 (the concentration causing 50% inhibition) being about 2.0 mM. Lineweaver-Burk plots indicated that the nature of this inhibition is mixed; intercept and slope replots are straight lines, showing that the inhibition is complete rather than partial. The value of Km for AChE is found to be 108 microM, while values of KI and Ki are found to be 1.5 and 5.1 mM, respectively, Ki is greater than KI indicating that uncompetitive inhibition is predominant over noncompetitive inhibition.

摘要

相似文献

1
The toxicological effect of cyclophosphamide on acetylcholinesterase activity.
Toxicol Lett. 1993 Feb;66(2):125-31. doi: 10.1016/0378-4274(93)90087-e.
2
Inhibition of human acetylcholinesterase by cyclophosphamide.环磷酰胺对人乙酰胆碱酯酶的抑制作用。
Toxicology. 1995 Jan 19;96(1):1-6. doi: 10.1016/0300-483x(94)02848-o.
3
The inhibitory effect of cyclophosphamide on camel retina acetylcholinesterase activity.环磷酰胺对骆驼视网膜乙酰胆碱酯酶活性的抑制作用。
Toxicol Lett. 1996 Oct;87(2-3):69-76. doi: 10.1016/0378-4274(96)03706-x.
4
Evaluation of the nature of camel retinal acetylcholinesterase: inhibition by hexamethonium.骆驼视网膜乙酰胆碱酯酶性质的评估：六甲铵对其的抑制作用
J Enzyme Inhib. 1997 Dec;12(4):303-11. doi: 10.3109/14756369709035822.
5
The nature of the inhibition of camel retina acetylcholinesterase (EC 3.1.1.7) activity by tetrahydroaminoacridine.四氢氨基吖啶对骆驼视网膜乙酰胆碱酯酶（EC 3.1.1.7）活性的抑制作用性质。
J Ocul Pharmacol Ther. 1996 Winter;12(4):503-14. doi: 10.1089/jop.1996.12.503.
6
Kinetics of the inhibition of acetylcholinesterase from desert cobra (Walterinnesia aegyptia) venom by local anesthetics: procaine and tetracaine.局部麻醉药（普鲁卡因和丁卡因）对沙漠眼镜蛇（埃及沃尔特氏蛇）毒液中乙酰胆碱酯酶的抑制动力学
J Enzyme Inhib. 1996 Oct;11(2):123-34. doi: 10.3109/14756369609036539.
7
Kinetic analysis of the toxicological effect of tacrine (Cognex) on human retinal acetylcholinesterase activity.他克林（安理申）对人视网膜乙酰胆碱酯酶活性的毒理学效应的动力学分析。
Toxicology. 2000 May 19;147(1):33-9. doi: 10.1016/s0300-483x(00)00177-3.
8
Kinetics of human erythrocyte acetylcholinesterase inhibition by cis-diamminediaquaplatinum (II).顺二氨二水合铂（II）对人红细胞乙酰胆碱酯酶的抑制动力学
Anticancer Res. 1997 Nov-Dec;17(6D):4487-91.
9
Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine.毒扁豆碱的一种新型衍生物：苯丝氨酸对人红细胞乙酰胆碱酯酶的抑制动力学
Biochem Biophys Res Commun. 1998 Jul 9;248(1):180-5. doi: 10.1006/bbrc.1998.8931.
10
Investigation of the effect of lannate on kinetic parameters of acetylcholinesterase: slightly concave mixed-type of inhibition system.兰纳特对乙酰胆碱酯酶动力学参数的影响研究：轻微凹形混合型抑制系统。
Biochem Mol Biol Int. 1997 Dec;43(6):1183-93. doi: 10.1080/15216549700205021.

引用本文的文献

1
In vitro inhibition of human erythrocyte acetylcholinesterase (EC3.1.1.7) by an antineoplastic drug methotrexate.一种抗肿瘤药物甲氨蝶呤对人红细胞乙酰胆碱酯酶（EC3.1.1.7）的体外抑制作用。
Mol Cell Biochem. 1996 Jun 7;159(1):47-53. doi: 10.1007/BF00226062.
2
Acetylcholinesterase from desert cobra (Walterinnesia aegyptia) venom: optimization and kinetics study.
Mol Cell Biochem. 1995 Oct 4;151(1):21-6. doi: 10.1007/BF01076891.