Qureshi A R, Wilkinson J H
Ann Clin Biochem. 1977 Jan;14(1):48-52. doi: 10.1177/000456327701400109.
During incubation with rabbit blood in vitro rabbit-muscle lactate dehydrogenase-5 was inactivated at a rate similar to that observed in vivo. By contrast plasma and plasma containing erythrocytes had no effect on the enzyme activity, but plasma containing leucocytes inactivated the enzyme at the same rate as whole blood. The results obtained support the concept that intravascular inactivation accounts for the diappearance of enzymes from the circulation.
在体外与兔血一起孵育期间，兔肌肉乳酸脱氢酶-5的失活速率与体内观察到的相似。相比之下，血浆和含有红细胞的血浆对酶活性没有影响，但含有白细胞的血浆使该酶失活的速率与全血相同。所得结果支持血管内失活导致酶从循环中消失这一概念。
