Wilson D V, Eberhart S W, Robinson N E, Rice R, Gray P R
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824.
Am J Vet Res. 1993 Feb;54(2):274-9.
The effects of exogenous platelet-activating factor (PAF) were determined in anesthetized ponies. Administration of PAF induced a decrease in cardiac index that resulted in systemic hypotension. This was followed by tachycardia, hypertension, and a return of cardiac index to baseline. Pulmonary arterial pressure increased markedly because of pulmonary vasoconstriction. Exogenous PAF also caused leukopenia and thrombocytopenia. The specific PAF receptor antagonist (WEB 2086) blocked all PAF-induced changes. Flunixin meglumine, a cyclooxygenase inhibitor, abolished the pulmonary hypertension and tachycardia, and attenuated the systemic hypotension but did not change the PAF-induced peripheral cellular changes. The PAF antagonist also inhibited platelet aggregation induced by PAF in vitro. The PAF-induced changes are similar to those reported after endotoxin exposure in horses.
在麻醉的小马身上测定了外源性血小板活化因子（PAF）的作用。给予PAF会导致心脏指数下降，进而引起全身性低血压。随后出现心动过速、高血压，心脏指数恢复至基线水平。由于肺血管收缩，肺动脉压显著升高。外源性PAF还会导致白细胞减少和血小板减少。特异性PAF受体拮抗剂（WEB 2086）可阻断所有PAF诱导的变化。氟尼辛葡甲胺，一种环氧化酶抑制剂，可消除肺动脉高压和心动过速，并减轻全身性低血压，但不会改变PAF诱导的外周细胞变化。PAF拮抗剂在体外也能抑制PAF诱导的血小板聚集。PAF诱导的变化与马暴露于内毒素后报道的变化相似。
