Curry M C, Montgomery H, Winkelmann R K
Arch Dermatol. 1977 Mar;113(3):316-9.
Whereas basal cell carcinoma usually is a slow-growing tumor of the head and neck region, we have observed, over a 20-year period, three large, unique basal cell tumors of the back that were distinctive and presented clinical and histologic problems in diagnosis. They commonly formed exophytic, vegetative, flesh-colored to red, sessile plaques up to 20 cm in diameter. Ulceration was the principal feature of a fourth tumor, which destroyed the skin of the entire lumbar area and invaded the muscle. Regional-node metastases from this tumor showed basal cell carcinoma. Histologically, all the primary lesions were adenoid basal cell carcinomas with mucinous stroma. Histochemistry in two cases demonstrated minimal respiratory enzymes and no special esterolytic or lysosomal enzymes. Surgery was curative in three of these cases of rare, giant variant of basal cell carcinoma of the skin.
基底细胞癌通常是一种生长缓慢的头颈部肿瘤，然而，在20年的时间里，我们观察到背部有三例巨大、独特的基底细胞肿瘤，它们具有独特性，在临床和组织学诊断方面存在问题。它们通常形成外生性、疣状、肉色至红色的无柄斑块，直径可达20厘米。溃疡是第四例肿瘤的主要特征，该肿瘤破坏了整个腰部区域的皮肤并侵犯了肌肉。该肿瘤的区域淋巴结转移显示为基底细胞癌。组织学上，所有原发性病变均为伴有黏液性间质的腺样基底细胞癌。两例的组织化学检查显示呼吸酶极少，且无特殊的酯解酶或溶酶体酶。在这些罕见的皮肤基底细胞癌巨大变种病例中，有三例通过手术治愈。
