Nagpal K C, Asdourian G K, Patrianakos D, Goldberg M F, Rabb M F, Goldbaum M, Raichand M
Arch Intern Med. 1977 Mar;137(3):325-8.
Seven patients had sickle cell trait (hemoglobin AS) and vasoproliferative retinopathy. The retinal abnormalities in these seven patients were indistinguishable from those seen in patients with clinically significant sickling hemoglobinopathies (sickle cell-hemoglobin C disease, hemoglobin S-thalassemia disease, and sickle cell anemia). All seven patients also had some evidence of associated systemic disease such as diabetes, syphilis, tuberculosis, or sarcoidosis. In the presence of an associated systemic disease, marked retinopathy can occur in the ordinarily benign condition of sickle cell trait.
7例患者患有镰状细胞性状（血红蛋白AS）和增殖性视网膜病变。这7例患者的视网膜异常与具有临床意义的镰状血红蛋白病（镰状细胞-血红蛋白C病、血红蛋白S-地中海贫血病和镰状细胞贫血）患者所见的异常无法区分。所有7例患者也都有一些相关全身性疾病的证据，如糖尿病、梅毒、结核病或结节病。在存在相关全身性疾病的情况下，通常为良性的镰状细胞性状可出现明显的视网膜病变。
