Rossi E, Taketani S, Garcia-Webb P
Clinical Biochemistry Department, Queen Elizabeth II Medical Centre, Nedlands, W.A., Australia.
Biomed Chromatogr. 1993 Jan-Feb;7(1):1-6. doi: 10.1002/bmc.1130070102.
Lead exposure causes increases in urinary coproporphyrin excretion and the accumulation of zinc protoporphyrin in red cells. In the conventional view of the effect of lead on haem biosynthesis, the accumulation of these metabolites results from lead inhibition of two of the mitochondrial enzymes of haem biosynthesis, coproporphyrinogen oxidase (EC 1.3.3.3) and ferrochelatase (EC 4.99.1.1). This review critically assesses the evidence for the inhibition of these enzymes. We consider this evidence to be inconclusive and alternative explanations for the increased concentrations of coproporphyrin and zinc protoporphyrin are proposed.
铅暴露会导致尿中粪卟啉排泄增加以及红细胞中锌原卟啉的积累。在关于铅对血红素生物合成影响的传统观点中，这些代谢产物的积累是由于铅抑制了血红素生物合成的两种线粒体酶，即粪卟啉原氧化酶（EC 1.3.3.3）和亚铁螯合酶（EC 4.99.1.1）。本综述批判性地评估了这些酶受到抑制的证据。我们认为该证据尚无定论，并提出了对粪卟啉和锌原卟啉浓度升高的其他解释。
